Obviously, there are thousands of acronyms–some that are actually used, some just made up so the list appears more comprehensive–but these are the ones I’m actually likely to use. Arranged for your convenience in alphabetical order. 🙂

AFAIC/AFAIK – as far as I’m concerned/as far as I know
AFU – all fucked up
AMFYOYO – Adios, motherfucker, you’re on your own
AYPI – and your point is?
BFD – big fucking deal
BFU – butt-fuckin’ ugly
DIAF – die in a fire
DILLIGAF – do I look like I give a fuck
EABOD – eat a bag of dicks
ESAD – eat shit and die
FOAD – fuck off and die
FSM – Flying Spaghetti Monster
FTL – for the lose
FTW – for the win
GBTW – get back to work
GG – gotta go (used with or without RFN, depending upon degree of urgency)
GTFO – get the fuck out, get the fuck off
IANAL – I am not a lawyer (prefaces legal advice, often incorrect)
IME – in my experience
IMHO – in my humble opinion
JAS/JAM – just a second/just a minute
JC – just curious
JFGI – just fucking google it
MMYF – my mistake, your fault
MSM – mainstream media (can’t speak for elsewhere, but in the US, television news channels are “infotainment”, not actual news; radio to a lesser extent)
NIMBY – not in my back yard (those who are pro-alternate energy…until someone tries to put wind turbines anywhere that “blocks my view and potentially lowers my property value”)
NM – never mind
NOMFB/NOMGB – none of my fucking business/none of my goddamned business
OOTB – out of the box
PITA – pain in the arse
POS – piece of shit
RFN – right fucking now
SOS – same old shit
STFU – shut the fuck up
TCR – The Colbert Report
TDS – The Daily Show
TFB – too fuckin’ bad
TL;DR – too long, didn’t read
TMI – too much information
YMMV – your mileage may vary